great. now I can't sleep. I decided to experiment and add cimetidine 400 mg po bid to the mix. for one thing, I do have GERD, but for the other, I wanted to see what inhibiting CYP3A4 (among others) would do to my levels of venlafaxine. (I did decide to go back down to Effexor XR 150 mg po daily.) I don't know if I'm happy or high. though I suppose there really isn't a difference when you come right down to it.